An efficient synthesis of (2S,3R)-3-hydroxylysine via ruthenium catalyzed asymmetric hydrogenation
| Autor: | Virginie Ratovelomanana-Vidal, Maria Cristina Caño de Andrade, Jean-Pierre Genêt, Estelle Coulon |
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| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element Sequence (biology) Biochemistry Combinatorial chemistry Ruthenium Amino acid Catalysis Kinetic resolution Hydroxylysine chemistry.chemical_compound chemistry Drug Discovery |
| Zdroj: | Tetrahedron Letters. 39:6467-6470 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(98)01387-2 |
| Popis: | An efficient synthesis of the natural occuring amino acid (2S,3R)-3-hydroxylysine is reported. The five step sequence features a highly enantioselective dynamic kinetic resolution of racemic α-acetamido β-keto phtalimidohexanoate using ruthenium(II) catalyzed hydrogenation reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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