Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers Implications of BNP, H-FABP, and PTX3
| Autor: | Olga Bilim, Isao Kubota, Takeshi Niizeki, Takuya Miyamoto, Toshiki Sasaki, Mitsunori Ishino, Joji Nitobe, Takehiko Miyashita, Yasuchika Takeishi, Tetsu Watanabe, Tatsuro Kitahara, Satoshi Suzuki |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.drug_class Inflammation Retrospective cohort study General Medicine PTX3 medicine.disease Predictive value of tests Heart failure Internal medicine Risk stratification cardiovascular system medicine Cardiology Natriuretic peptide medicine.symptom Cardiology and Cardiovascular Medicine Risk assessment business |
| Zdroj: | Circulation Journal. 72:1800-1805 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | Background B-type natriuretic peptide (BNP), heart-type fatty acid-binding protein (H-FABP), and pentraxin 3 (PTX3) each predict adverse cardiac events in chronic heart failure (CHF) patients. For prognostic evaluation from different aspects, the utility of combined measurement of the 3 biomarkers in patients with CHF was examined in the present study. Methods and Results Levels of BNP (associated with left ventricular dysfunction, positive if >200 pg/ml), H-FABP (marker of myocardial damage, positive if >4.1 ng/ml), and PTX3 (marker of inflammation, positive if >4.0 ng/ml) were measured in 164 consecutive CHF patients, and patients were prospectively followed with endpoints of cardiac death or rehospitalization. When patients were categorized on the basis of the number of elevated biomarkers, patients with 1, 2, and 3 elevated biomarkers had a 5.4-fold (not significant), 11.2-old (p |
| Databáze: | OpenAIRE |
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