Synthesis and crystal structure of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine. inhibitory properties of 3′-fluoro-3′-methyl-2′,3′-dideoxythymidine-5′-triphosphate in the synthesis of DNA in cell-free media
| Autor: | Maxim V. Jasko, Antonia A. Nikitenko, Lubov S. Viktorova, Ving J. Lee, Valery E. Zavodnik, Dmitzy G. Semizarov, B. M. Arshava, Anatoly D. Shutalev, Yuri E. Raifeld, Galina V. Gurskaya, Galina Ya. Vid, Igor E. Mikerin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
DNA synthesis Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Crystal structure Biochemistry Thymine Cell-free system chemistry.chemical_compound Enzyme chemistry Dideoxynucleotide Drug Discovery Molecular Medicine Molecule Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:761-768 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80197-9 |
| Popis: | The synthesis, physicochemical properties and chain-termination properties of 3′-fluoro-3′-methyl-2′-3-dideoxythymidine is described. The synthesis was accomplished b the coupling of bis(TMS)thymine with 3-fluoro-3-methyl-2,3-dideoxy-D-erythro-pentose which is obtained from non-carbohydrate precursors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|