Białaczka włochatokomórkowa oporna na standardową terapię analogiem puryn – opis przypadku i przegląd piśmiennictwa
| Autor: | Klaudia Grądzka, Kamila Kruczkowska-Tarantowicz, Janusz Kloczko, Marzenna B. Klimiuk |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nucleoside analogue business.industry Hematology Pharmacology medicine.disease Gastroenterology First line treatment Oncology Refractory Chemoimmunotherapy hemic and lymphatic diseases Internal medicine medicine Hairy cell leukemia Rituximab business Cladribine Single cycle medicine.drug |
| Zdroj: | Acta Haematologica Polonica. 44:340-343 |
| ISSN: | 0001-5814 |
| DOI: | 10.1016/j.achaem.2013.07.011 |
| Popis: | Hairy cell leukemia (HCL) is a rare, chronic lymphoproliferative disorder. Currently, purine nucleoside analogs (PNA) constitute the first line treatment of HCL. Cladribine could induce long lasting remission in majority of patients with only a single cycle of therapy. In fact the relapsed patients could be treated successfully with cladribine too. Sometimes we observe the resistance to PNA. Rituximab and chemoimmunotherapy (rituximab plus cladribine) are effective in treatment of refractory HCL. We present a case of a 64-year-old man who was treated with rituximab after second progression of HCL. In March 2011, rituximab was given at a dose of 375 mg/m 2 i.v. once a week for eight weeks, with result of achievement of PR. During the last hospitalization in March 2013 the persistence of PR was confirmed. |
| Databáze: | OpenAIRE |
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