ChemInform Abstract: Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon

Autor:	Yutana Pongpiriyadacha, Makoto Hamao, Hisashi Matsuda, Masako Hongo, Yasunobu Asao, Sachiko Sugimoto, Masayuki Yoshikawa, Seikou Nakamura
Rok vydání:	2009
Předmět:	Lignan Aldose reductase Sucrose biology Triglyceride Stereochemistry Dimer Cotylelobium melanoxylon Trimer General Medicine biology.organism_classification chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Bark
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200942197
Popis:	The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil loading in mice. A new stilbene dimer, melanoxylin A, together with the known stilbene dimers [(+)-ampelopsin F, (+)-isoampelopsin F, and (+)-e-viniferin] and a trimer (vaticanol G) and a lignan [(+)-lyoniresinol] were isolated from the wood extract, and a new stilbene trimer, melanoxylin B, together with the known stilbene dimers [(+)-e-viniferin and cis-(+)-e-viniferin] and trimers (vaticanols A, E, and G) were isolated from the bark extract of C. melanoxylon. The principal constituents, vaticanols A, E, and/or G, inhibited plasma glucose and triglyceride elevation after sucrose loading in rats and olive oil loading in mice, respectively. In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal α-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c98d258b76f06b98ccb53e65bc4acdf https://doi.org/10.1002/chin.200942197 Zobrazit plný text záznamu Plný text