Association between Cytokine Gene Polymorphisms and Breast Cancer in Postmenopausal Women

Autor: Elena G. Polenok, Elena N. Voronina, A. N. Glushkov, V. A. Lutsenko, Ekaterina A. Sokolova, A. V. Antonov, N. E. Verzhbitskaya, L. A. Gordeeva, S. A. Mun, Maksim L. Filipenko
Rok vydání: 2021
Předmět:
Zdroj: Advances in Gerontology. 11:44-52
ISSN: 2079-0589
2079-0570
Popis: The goal of this study was to investigate the association between the polymorphic loci of genes IL1B (rs16944), IL1RN (rs4251961), IL6 (rs1800795, rs1800796, rs1554606), IL8 (rs4073), IL10 (rs1800896), and TNFA (rs1800629) and breast cancer in women. The DNA samples of 521 women with breast cancer and 267 women without oncological pathology were studied. The study showed that age, concomitant chronic morbidity, and polymorphism of the IL6 gene are risk factors in postmenopausal women. Allele –572C (OR = 5.68; 95% CI = [2.70–11.97], pcor < 0.001), and haplotype rs1800796[C]–rs1800795[G]–rs1554606[G] (OR = 5.31, 95% CI = [1.87 – 15.10], pcor = 0.002) of the IL6 gene were associated with breast cancer. No association of loci in IL1B (rs16944), IL1RN (rs4251961), IL8 (rs4073), IL10 (rs1800896), or TNFA (rs1800629) was associated with the risk of breast cancer. The obtained data indicate that the –572C allele of the IL6 gene is associated with susceptibility in postmenopausal women to breast cancer. Our results can be useful for an understanding of the molecular mechanisms of breast cancer.
Databáze: OpenAIRE
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