In vitro antibacterial, antifungal, and DNA cleavage studies of coumarin Schiff bases and their metal complexes: synthesis and spectral characterization
| Autor: | Prema S. Badami, Shrishila N. Unki, Sangamesh A. Patil |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
biology
Stereochemistry Organic Chemistry Aspergillus niger Aspergillus flavus biology.organism_classification medicine.disease_cause Coumarin Metal chemistry.chemical_compound chemistry visual_art Agarose gel electrophoresis visual_art.visual_art_medium medicine Chelation General Pharmacology Toxicology and Pharmaceutics Cyclic voltammetry Escherichia coli Nuclear chemistry |
| Zdroj: | Medicinal Chemistry Research. 21:4017-4027 |
| ISSN: | 1554-8120 1054-2523 |
| Popis: | A series of metal complexes of the type ML·2H2O [M = Co(II), Ni(II), and Cu(II)] have been synthesized with newly synthesized Schiff bases derived from 1,8-diaminonaphthalene and 8-formyl-7-hydroxy-4-methylcoumarin/8-acetyl-7-hydroxy-4-methylcoumarin. The chelation of the metal complexes has been proposed in the light of analytical, spectral (IR, NMR, UV–Vis, ESR, and FAB-mass), magnetic, and thermal studies. The redox behavior of the complexes was investigated by electrochemical method using cyclic voltammetry. The Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by minimum inhibitory concentration method. The results of these studies show the metal complexes to be more effective antibacterial and antifungal as compared with the uncomplexed coumarins. DNA cleavage is studied by agarose gel electrophoresis method. |
| Databáze: | OpenAIRE |
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