The Volume of Solitary Parathyroid Adenoma is Related to Preoperative PTH and 250H-D3, but Not to Calcium Levels
| Autor: | Carmen Vulpoi, Gatu A, Cristina Preda, Dumitru Branisteanu, Mogoş, Simona Mogos, Muntean, Radu Danila, Cristian Velicescu, Alexandru Grigorovici |
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| Rok vydání: | 2017 |
| Předmět: |
Medical unit
medicine.medical_specialty Adenoma Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism Urology chemistry.chemical_element Calcium medicine.disease vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Endocrinology chemistry 030220 oncology & carcinogenesis medicine Vitamin D and neurology 030223 otorhinolaryngology business hormones hormone substitutes and hormone antagonists Primary hyperparathyroidism Hormone Parathyroid adenoma |
| Zdroj: | Acta Endocrinologica (Bucharest). 13:441-446 |
| ISSN: | 1843-066X 1841-0987 |
| DOI: | 10.4183/aeb.2017.441 |
| Popis: | Purpose To correlate the volume of parathyroid adenomas with the hormonal and metabolic profile at patients diagnosed with primary hyperparathyroidism (pHPTH). Patients and Methods Cross-sectional multicentric study, enrolling 52 patients with pHPTH from two medical institutions. Serum calcium and PTH were evaluated in all patients before surgery, whereas 25OHD3 was measured only in the 33 patients recruited form one medical unit. The volume of parathyroid adenoma was measured by using the formula of a rotating ellipsoid. Results We observed a significant correlation of the volume of parathyroid adenomas with PTH at patients from the two units and in the whole group (p < 0.0001), but not with serum calcium (p = 0.494). Twenty-five out of the 33 patients at whom 25OHD3 was measured had levels in the range of deficiency. 25OHD3 was not correlated with PTH or calcium levels, but was negatively correlated to the adenoma volume and positively to the PTH/volume ratio (p = 0.041 and p = 0.048, respectively). Conclusions The volume of parathyroid adenoma seems to be related to preoperative PTH and 25OHD3, but not to calcium level. Vitamin D deficiency is frequently found at patients with pHPTH and may contribute to particular disease profiles, including larger parathyroid adenomas. |
| Databáze: | OpenAIRE |
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