| Autor: |
Abhishek Kumar, Prashant Nayak, Soundarya M. Rai, Pankaj Kumar, Alphonsus D’souza |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmaceutical Research International. :134-144 |
| ISSN: |
2456-9119 |
| Popis: |
A series of substituted dihydro-1, 2-oxazole benzopyran-2-one (SR1-SR6) were synthesized through the intermediate substituted benzopyran-2-one chalcones and were characterized using spectral analysis. Compounds were docked with receptor DNA Gyrase B (PDB code: 5L3J) to know its interaction and binding energy; ranges -3.38 to -2.15 kcal/mol. Further these compounds were tested for antibacterial activity using tube dilution method and MIC values were observed; ranges 3.12 to 25 µg/ml. Compound 3-(5-(m-tolyl)-4,5-dihydroisoxazol-3-yl)-2H-chromen-2-one (SR3) showed the best interaction with binding energy -3.38 kcal/mol and antimicrobial activity having MIC 3.12 µg/ml. GRAPHICAL ABSTRACT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
