| Autor: |
Fu-Min Zhang, Ai-Jun Ma, Ming-Hui Xu, Jin-Bao Peng, Yong-Hai Yuan, Kun Zhang, Yong-Qiang Tu, Dong-Dong Liang, Xiao-Ming Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Organic Chemistry Frontiers. 8:3292-3297 |
| ISSN: |
2052-4129 |
| DOI: |
10.1039/d1qo00238d |
| Popis: |
A novel spiro-pyrrolidine (SPD)-derived bifunctional thiourea catalyst has been developed, enabling the development of a stereoselective conjugate addition of furfurals to β,γ-unsaturated α-ketoesters. The reaction represents an example of asymmetric trienamine catalysis in the benzylic C–H functionalization of 5-benzylfurfurals, and the rigid spirocyclic framework of the catalyst is proven to be essential for a highly enantioselective transformation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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