| Popis: |
Publisher Summary Knowledge of photodynamic therapy has increased substantially. So much so that it is now an approved treatment for various cancers and subsequent uses for PDT are being determined regularly. Although it is well known that PDT is very toxic under specific circumstances and conditions, there is much to learn about its exact mode of action. For overall photodamage, the initial reaction is of less importance as both type I and type II reactions lead to similar oxidative damage and can lead to comparable radical chain reactions in the presence of oxygen. Overall, the effect of either type I or type II reactions is the production of oxidative damage within the cell, which will ultimately lead to cell death. Where distinguishing between these two reaction pathways becomes important is in order to thoroughly understand how PDT actually works so that the modulation of its effect can be achieved to maximize the biological effect. It is highly unlikely that a given photosensitizer or a given PDT mechanism is ideal for every application. It is only in completely understanding the processes involved that ideal compounds and conditions can be determined for each use. |
