| Autor: |
Abdurazak J. Tura, Ameeduzzafar Zafar, Teshome Gebissa, K.M. Noorulla, Sultan Alshehri, Shimelis Mekit, Mohammed M. Ghoneim, Alanood S. Almurshedi, Roshan S, Mohammed Muqtader Ahmed, Mohd Yasir, Faizi Muzaffar |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Drug Delivery Science and Technology. 67:102939 |
| ISSN: |
1773-2247 |
| DOI: |
10.1016/j.jddst.2021.102939 |
| Popis: |
The current research was portrayed to design and optimize Chitosan (CH) coated Buspirone-loaded nanostructured lipid carriers (BPE-CH-NLCs) for nose to brain delivery. NLCs were developed by solvent diffusion evaporation technique, coated with CH, and then optimized to the maximum efficiency using the quality by design (QbD) based Box-Behnken design (BBD). Glyceryl monostearate (GMS) & oleic acid mixture and tween 80 were used as a lipid and surfactant, respectively. The prepared NLCs were subjected to in-vitro characterization. In-vivo pharmacokinetic and neuro-pharmacokinetic (drug targeting efficiency-DTE, direct transport percentage-DTP) parameters were evaluated on Wister rats. The results revealed that the optimized formulation exhibited acceptable PS (190.98 ± 4.72 nm), ZP (−17.47 mV), and EE (80.53 ± 1.26% w/w), and the TEM image showed that the drug was incorporated adequately in NLCs. DSC findings exposed that the drug was present in amorphous form within the NLCs. The optimized formulation exhibited 27.61 months shelf life and was found to be stable under stated conditions. The value of AUC (bioavailability) for BPE-CH-NLCs administered i.n was found to be 3.06 folds compared to BPE-CH-NLCs administered i.v, and 2.17 folds compared to BPE-Sol administered i.n. A higher value of DTE (1462.49%) for developed NLCs confirmed the brain targeting efficiency of these lipid nanoparticles. DTP value for BPE-CH-NLCs (93.16%) was significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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