Synthesis of aurone derivatives on the basis of 2,4,6-trihydroxytoluene

Autor:	Alexey M. Starosotnikov, Natal’ya L. Merkulova, K. I. Kobrakov, Dmitry N. Kuznetsov, Dmitry A. Shubin
Rok vydání:	2019
Předmět:	Cyperus capitatus chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Aurone Capitata Organic chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences
Zdroj:	Chemistry of Heterocyclic Compounds. 55:1174-1178
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-019-02597-0
Popis:	2,4,6-Trihydroxytoluene (2-methylphloroglucinol) was used as starting material for the first synthesis of several (Z)-2-arylidene-4,6-dihydroxy-7-methylaurones, including a synthetic analog of the natural 7-methylaureusidin, which is currently obtained mainly from the extract of sedge capitata (Cyperus capitatus). It was shown that the reaction of 2,4,6-trihydroxytoluene with chloroacetonitrile occurred regioselectively, with the formation of 4,6-dihydroxy-7-methylbenzofuran-3(2H)-one, the treatment of which with substituted benzaldehydes gave high yields of the target compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c6e1de0666edf185fbd0a006f7b830a https://doi.org/10.1007/s10593-019-02597-0 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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