Evaluation of Uric Acid, Total Antioxidant and Lipid Peroxidation Parameters in Serum and Saliva of Patients with Oral Lichen Planus
| Autor: | Shahin Arab, Atena Shiva |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Saliva Population medicine.disease_cause Gastroenterology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system Internal medicine medicine education chemistry.chemical_classification education.field_of_study Reactive oxygen species business.industry 030206 dentistry General Medicine Malondialdehyde medicine.disease stomatognathic diseases chemistry 030220 oncology & carcinogenesis Immunology Uric acid Oral lichen planus business Oxidative stress |
| Zdroj: | Global Journal of Health Science. 8:225 |
| ISSN: | 1916-9744 1916-9736 |
| Popis: | BACKGROUND: Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.OBJECTIVE: To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples.MATERIAL & METHODS: The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman’s rho correlation coefficient for assessing association between serum and salivary fluids.RESULTS: TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values.CONCLUSION: This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance. |
| Databáze: | OpenAIRE |
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