Cerebrospinal fluid-orexin decreases during intraventricular alpha-interferon therapy of the patients with subacute sclerosing panencephalitis
| Autor: | Yuriko Ogawa, Tetsuo Shimizu, Tamami Yano, Yukio Sawaishi, Yasushi Saito, Takashi Kanbayashi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Neurology α interferon Physiology business.industry digestive oral and skin physiology Promoter medicine.disease Subacute sclerosing panencephalitis Orexin Neuropsychology and Physiological Psychology Cerebrospinal fluid Endocrinology Physiology (medical) Internal medicine Cerebral ventricle medicine business hormones hormone substitutes and hormone antagonists Normal range |
| Zdroj: | Sleep and Biological Rhythms. 1:143-145 |
| ISSN: | 1479-8425 1446-9235 |
| Popis: | We determined the orexin concentration in cerebrospinal fluid (CSF-OX) in two patients with subacute sclerosing panencephalitis who underwent intracerebroventricular (ICV) α-interferon (IFN-α) therapy. In these patients, CSF-OX were in the normal range before ICV administration of IFN-α, and it decreased to undetectable levels after the initiation of IFN-α therapy. It was reported that the production of prepro-OX, which is a precursor of OX, was prevented when IFN-α was given to the gene promoter region of prepro-OX. These results suggest that the production of OX may be suppressed by inhibition of promotor activity when IFN-α is given to the cerebral ventricle in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|