Molecular genetic findings in small bowel neuroendocrine neoplasms: a review of the literature
| Autor: | Andrea Frilling, Mark Kidd, Helen C Miller, Leandro Castellano |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Economics and Econometrics
Treatment response business.industry Tumor biology Forestry Bioinformatics law.invention Circulating tumor cell Randomized controlled trial law Immunology Materials Chemistry Media Technology Medicine Identification (biology) Personalized medicine Epigenetics Liquid biopsy business |
| Zdroj: | International Journal of Endocrine Oncology. 2:143-150 |
| ISSN: | 2045-0877 2045-0869 |
| Popis: | Small bowel neuroendocrine neoplasms (SBNEN) are the most common small bowel tumor and have an increasing incidence. Despite many treatment options, therapeutic strategy remains a key clinical challenge due to the paucity of large-scale, randomized controlled trials. The heterogeneity of SBNEN coupled with a lack of detailed information about the tumor biology, impedes patient stratification into groups based on tumor phenotypes or treatment response. More detailed analysis of the genetic and epigenetic characteristics of SBNEN, will allow treatment to move toward a more personalized medicine approach through the identification of novel biomarkers and therapeutic targets, with the aim to increase survival. |
| Databáze: | OpenAIRE |
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