540 Adverse Reactions in Statin Therapy at Younger and Children Older Then Twelve Years
| Autor: | Ceman J Saric, Haris Niksic, M. Miokovic, D Abduzaimovic, S Putica, Amina Selimovic, A Bajraktarevic, S Trninic, Z Margeta, S Majstorovic, Z Begic |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Heart disease business.industry Cholesterol Mevalonic acid Overweight medicine.disease High cholesterol chemistry.chemical_compound Blood pressure chemistry Internal medicine Diabetes mellitus Pediatrics Perinatology and Child Health medicine lipids (amino acids peptides and proteins) medicine.symptom business Adverse effect |
| Zdroj: | Pediatric Research. 68:277-277 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-201011001-00540 |
| Popis: | Background: Obesity in childhood bodes ill for future cardiovascular risk. HMG-CoA reductase is an enzyme in the cholesterol biosynthetic pathway that catalyses the conversion of HMG-CoA to mevalonic acid. Statins are a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Aims: The most controversial change appears to have been the inclusion of statins as potential firstline pharmacologic agents in older children. Methods: High-risk children, include those who are obese or overweight and who also have high blood pressure, or diabetes, or a positive family history of either high cholesterol or early heart disease. The safety of statins in children and adolescents is based on trials that have ranged in duration from six months to one year. Results: Inhibition of this enzyme in the liver results in decreased cholesterol synthesis as well as increased synthesis of LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream. The first results can be seen after one week of use and the effect is maximal after four to six weeks. No serious laboratory adverse events were reported during follow-up, and statin treatment had no untoward effects on sexual maturation. Conclusion: The recommendation to use statins in childhood seems to have hit a collective nerve, perhaps awakening us to the fuller implications of the obesity epidemic. Statins exhibit action beyond lipid-lowering activity in the prevention of atherosclerosis. |
| Databáze: | OpenAIRE |
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