Alterations in serum lipid profile in critically ill septic patients: a prospective study

Autor: Irene Karampela, Apostolos Armaganidis, Panagiotis Simitsis, George Antonakos, Evangelia Kandri, Maria Dalamaga, George Skyllas, Gerasimos Socrates Christodoulatos, Evangelia Chrysanthopoulou
Rok vydání: 2020
Předmět:
Zdroj: Acute critical care.
DOI: 10.1183/13993003.congress-2020.2753
Popis: Aims and Objectives: Sepsis results in severe lipid metabolic alterations. Lipids exert important immunomodulatory actions during infection. We aim to investigate whether serum lipid changes early in sepsis are associated with severity and outcome. Methods: In a prospective study, serum total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TG) were determined in 82 critically ill patients (49 males, age 65±14 years, APACHE II 23±7, SOFA 10±3) at sepsis onset and one week after, and in 82 age and gender-matched healthy controls. Results: Upon enrollment, TC, HDL and LDL were significantly lower and TG were higher in patients compared to controls (p Conclusions: Critically ill septic patients exhibit significant alterations of serum lipids associated with sepsis severity and outcome.
Databáze: OpenAIRE