Synthesis, Anti-Inflammatory Properties and Molecular Docking of 2-(5-Aryltetrazol-2-yl)-and 2-(1H-Tetrazol-5-ylsulphanyl)-N-Thiazol-2-ylacetamides

Autor:	V. T. Foliush, V. V. Ogurtsov, T. I. Chaban, Vasyl S. Matiychuk
Rok vydání:	2021
Předmět:	biology Chemistry Stereochemistry medicine.drug_class Organic Chemistry Reference drug Ibuprofen Biochemistry Anti-inflammatory Active center biology.protein medicine Bioorganic chemistry Cyclooxygenase medicine.drug
Zdroj:	Russian Journal of Bioorganic Chemistry. 47:889-895
ISSN:	1608-330X 1068-1620
DOI:	10.1134/s1068162021040051
Popis:	By the reaction of chloroacetamidothiazole with 5-aryltetrazoles and 5-mercaptotetrazoles 2-(5-aryltetrazol-2-yl)- and 2-(1H-tetrazol-5-ylsulfanyl)-N-thiazol-2-ylacetamides were prepared. The study of the anti-inflammatory properties of the synthesized compounds was carried out. Compounds have been identified, whose activity exceeds the reference drug ibuprofen. Molecular docking to cyclooxygenase-1 and cyclooxygenase-2 was carried out and it was shown that 2-[1-(2,5-dimethylphenyl)-1H-tetrazol-5-ylsulfanyl]-N-thiazol-2-ylacetamide has the highest affinity for the active center of the cyclooxygenase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c54a34155fb0bd673915f0071979986 https://doi.org/10.1134/s1068162021040051 Zobrazit plný text záznamu Full text from SpringerLink