Sacral Nerve Modulation Has No Effect on the Postprandial Response in Irritable Bowel Syndrome
| Autor: | Klaus Krogh, Søren Laurberg, Janne Fassov, Donghua Liao, Lilli Lundby, Christina Brock |
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| Rok vydání: | 2020 |
| Předmět: |
Meal
medicine.medical_specialty business.industry Gastroenterology Stimulation medicine.disease 03 medical and health sciences 0302 clinical medicine Postprandial Gastrointestinal disorder 030220 oncology & carcinogenesis Internal medicine Statistical significance medicine Sacral nerve 030211 gastroenterology & hepatology business Gastrocolic reflex Irritable bowel syndrome |
| Zdroj: | Clinical and Experimental Gastroenterology. 13:235-244 |
| ISSN: | 1178-7023 |
| DOI: | 10.2147/ceg.s245209 |
| Popis: | Purpose Irritable bowel syndrome is a common gastrointestinal disorder with a global prevalence of approximately 11%. Onset or worsening of symptoms following digestion is one of the characteristics of the condition. The present study aimed at evaluating the postprandial sensory and motor response before and after treatment with sacral nerve modulation. Patients and methods Twenty-one irritable bowel syndrome patients, 12 diarrhea-predominant and 9 mixed, were eligible for a 6-week sacral nerve modulation test period. Patients were investigated with multimodal impedance planimetry including a standardized meal at baseline and at the end of 2 weeks of suprasensory stimulation embedded in the 6-week sacral nerve modulation period. Results There was no statistical significant difference in the sensory response to heat or cold before and after sacral nerve modulation, p>0.05. At baseline, wall tension increased after the meal (mean 124.79 [range 82.5 to 237.3] mmHg.mm before the meal, mean 207.76 [range, 143.5 to 429] mmHg.mm after the meal), p=0.048 indicating a postprandial response. During sacral nerve modulation, the postprandial increase in wall tension did not reach statistical significance (mean 86.79 [range 28.8 to 204.5] mmHg.mm before the meal, mean 159.71 [range 71.3 to 270.8] mmHg.mm after the meal), p=0.277. However, there was no statistically significant difference between the postprandial wall tension at baseline and during sacral nerve modulation, p=0.489. Likewise, we found no difference between pressure or stretch ratio at baseline and during sacral nerve modulation, p>0.05. Conclusion Sacral nerve modulation does not exert its positive treatments effects in diarrhea-predominant and mixed irritable bowel syndrome through a modulation of the postprandial response. |
| Databáze: | OpenAIRE |
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