Imprint Cytology of Epithelioid Angiomyolipoma in a Patient with Tuberous Sclerosis
| Autor: | Toshiaki Sano, Mitsuyoshi Hirokawa, Kazuhito Takamura, Akiko Hino |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Angiomyolipoma integumentary system business.industry General Medicine medicine.disease Pathology and Forensic Medicine Metastasis Tuberous sclerosis Renal cell carcinoma Cytopathology hemic and lymphatic diseases Hepatocellular carcinoma medicine Hyperchromasia business Epithelioid cell |
| Zdroj: | Acta Cytologica. 46:545-549 |
| ISSN: | 1938-2650 0001-5547 |
| DOI: | 10.1159/000326875 |
| Popis: | BACKGROUND: Angiomyolipoma composed predominantly of epithelioid cells has been referred to as epithelioid angiomyolipoma. As this subtype shows considerable cellular atypia, it may be erroneously diagnosed as malignant epithelioid tumor, such as renal cell carcinoma and hepatocellular carcinoma. So far, only one report describing the cytologic findings of epithelioid angiomyolipoma has been documented, and epithelioid angiomyolipoma occurring in the peritoneal cavity has not been reported. CASE: Eleven years after resection of a renal epithelioid angiomyolipoma in a 34-year-old male with tuberous sclerosis, a tumor appeared in the peritoneal cavity and three masses in the liver. The intraoperative smears imprinted from part of the peritoneal mass revealed many large, atypical cells. The well-preserved atypical cells showed abundunt, round to polyhedral, granular cytoplasm. Bizarre, giant nuclei with hyperchromasia and huge nucleoli were occasionally seen. Intranuclear cytoplasmic inclusions and mitotic figures were occasionally observed. As the epithelioid cells were markedly pleomorphic, we could not rule out hepatocellular carcinoma, cytologically and histologically, in the intraoperative consultation. In permanent sections the tumor was composed predominantly of epithelioid cells showing an alveolar pattern or sheetlike arrangement. Mitotic counts were zero to one per 10 high-power fields. Immunohistochemically, the epithelioid tumor cells were positive for vimentin, alpha-smooth muscle actin and HMB-45, consistent with epithelioid angiomyolipoma. MIB-1-labeling index was 1.6%. CONCLUSION: When one sees atypical epithelioid tumor cells in a tuberous sclerosis patient during an intraoperative consultation, one must consider epithelioid angiomyolipoma. |
| Databáze: | OpenAIRE |
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