Structurally Diverse Meroterpenoids from a Marine-Derived Aspergillus sp. Fungus
| Autor: | Qian Liu, Hucheng Zhu, Qin Li, Shuangjun Li, Yonghui Zhang, Jianping Wang, Huiling Wen, Yi Zang, Chunmei Chen, Xiliang Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Aspergillus biology 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Pharmaceutical Science Fungus biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Drug Discovery Molecular Medicine Moiety |
| Zdroj: | Journal of Natural Products. 83:99-104 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Three new meroterpenoids, asperaustins A–C (1–3), and seven known analogues (4–10) were isolated from a marine-derived Aspergillus sp. fungus. The structures and absolute configurations of these new compounds were unequivocally determined by extensive spectroscopic analyses and single-crystal X-ray diffraction analyses. Asperaustin A (1) possesses an unusual spiro[4.5]deca-3,6-dien-2-one moiety with a unique 5/6/6/6/5 pentacyclic skeleton. The absolute configurations of austinoneol A (7) and precalidodehydroaustin (9) were determined by single-crystal X-ray diffraction analyses using Cu Kα radiation for the first time. |
| Databáze: | OpenAIRE |
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