Formulation and evaluation of fast dissolving oral wafers of linagliptin
| Autor: | P. G Dhone, Zopate Pravin, Sahu Madhusmita, Gundawar Nilesh, Manisha S Lalan |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :3630-3640 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns5.9567 |
| Popis: | Wafers are modern oral dosage forms which are commonly used by patients worldwide. Also, in acute pain, these dosage types can be used to get immediate relief. These oral sublingual wafers are nothing more than a thin oral stripe which dissolves immediately due to the presence of saliva in the mouth when placed in the sublingual cavity by releasing medication within a short span of time. The faster dissolution can be achieved by using different superdisintegrants in different concentrations and a comparative study of different superdisintegrants has been carried out. Present investigation aims to formulate fast dissolving wafer of linagliptin using different film forming agents. From the latest research it can be inferred that fast-dissolving oral films of drug release are preferable. The films prepared by HPMC K4 and K15 and CCS and CP had shown strong mechanical power, release of narcotics, period for disintegration and analysis of dissolution. F7 formulation is considered the better with less disintegrating time and release in 10 min according to the results obtained. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges. |
| Databáze: | OpenAIRE |
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