Modeling, solubility, and thermodynamic aspects of sodium phenytoin in propylene glycol–water mixtures
| Autor: | Anahita Fathi-Azarjbayjani, Fleming Martínez, Abolghasem Jouyban, Arezoo Mabhoot |
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| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Enthalpy 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Sodium phenytoin 01 natural sciences Polyvinyl alcohol Atomic and Molecular Physics and Optics 0104 chemical sciences Electronic Optical and Magnetic Materials Gibbs free energy symbols.namesake chemistry.chemical_compound Materials Chemistry Gibbs–Helmholtz equation symbols Physical chemistry Physical and Theoretical Chemistry Solubility 0210 nano-technology Dissolution Spectroscopy Van 't Hoff equation |
| Zdroj: | Journal of Molecular Liquids. 219:68-73 |
| ISSN: | 0167-7322 |
| DOI: | 10.1016/j.molliq.2016.02.089 |
| Popis: | The solubility of sodium phenytoin in binary mixtures of propylene glycol and water at 298.2, 303.2, 308.2, and 313.2 K was measured. The effect of solvent composition on the thermodynamic properties of the dissolution process, including enthalpy, entropy, and Gibbs energy were studied based on van't Hoff analysis and the Gibbs equation. Experimental solubility was determined using the shake-flask method and the resulting data were correlated with the Jouyban–Acree model and with the Jouyban–Acree model in combination with the van't Hoff equation. |
| Databáze: | OpenAIRE |
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