Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones
| Autor: | Mohammed Yagoub Jomaa, Saeed Ahmad, Abdul Rajjak Shaikh, Saheed A. Popoola, Abdulaziz A. Al-Saadi, Gaurav Bhatia, Anvarhusein A. Isab, Jatinder Singh, Adam A.A. Seliman |
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| Rok vydání: | 2019 |
| Předmět: |
Cisplatin
010405 organic chemistry Stereochemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Carboplatin In vitro 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Docking (molecular) Materials Chemistry medicine Cytotoxic T cell Physical and Theoretical Chemistry Platinum Breast carcinoma DNA medicine.drug |
| Zdroj: | Inorganica Chimica Acta. 484:347-351 |
| ISSN: | 0020-1693 |
| Popis: | Ten cisplatin-derived platinum(II) complexes of thiones having the general formula, cis-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized by elemental analysis, IR and NMR (1H & 13C) methods. The spectroscopic data is in agreement with the coordination of thiones to platinum(II). The in vitro cytotoxic properties of all these complexes have been investigated against three human cancer cell lines, which include; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer) and compared to the therapeutically used anticancer agents, cisplatin and carboplatin. The in vitro cytotoxicities in several cases are higher than carboplatin but in all cases are lower than cisplatin. Docking studies are carried out to understand the possible binding mode of interaction of these compounds with DNA. |
| Databáze: | OpenAIRE |
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