Quality by Design (QbD) Approach to Develop and Validate a HPLC Method for Piroxicam from Serum
| Autor: | Iuliean Vasile Asaftei, Adrian Spac, Alina Monica Miftode, Ion Sandu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chromatography
Chemistry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine 010402 general chemistry Piroxicam 01 natural sciences General Biochemistry Genetics and Molecular Biology Quality by Design 0104 chemical sciences Materials Chemistry medicine General Pharmacology Toxicology and Pharmaceutics Hplc method medicine.drug |
| Zdroj: | Revista de Chimie. 69:2167-2171 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.18.8.6492 |
| Popis: | Piroxicam belongs to the non-steroidal antiinflammatory class, it is utilized as analgesic, anti-inflammatory and antipyretic. A simple and accurate HPLC method was optimized and validated in the QbD approach, for the determination of piroxicam in serum. The optimization of HPLC analysis was performed using different columns, mobile phases and flows. The HPLC method was appropriately validated for linearity, limit of detection, limit of quantification, precision and accuracy in accordance with the ICH guidelines. The optimized and validated method proved to be simple, precise, and accurate, and can be successfully applied for the determination of piroxicam in serum. |
| Databáze: | OpenAIRE |
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