Design, synthesis and biological evaluation of novel glucokinase activators

Autor:	Quan Liu, Yu Liang Zhang, Yu Ling Wang, Sheng Quan Hu, Yong Qiang Li, Zhiqiang Feng, Zhu Fang Shen, Lei Lei, Hong Rui Song
Rok vydání:	2011
Předmět:	chemistry.chemical_compound Biochemistry Design synthesis Chemistry Glucokinase Glucokinase activity General Chemistry Reference drug Benzamide Biological evaluation
Zdroj:	Chinese Chemical Letters. 22:73-76
ISSN:	1001-8417
Popis:	A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure–activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c35bdd5a1e722d92a16e9e40ecab751 https://doi.org/10.1016/j.cclet.2010.07.023 Zobrazit plný text záznamu Full Text from ScienceDirect