One‐Pot Enzyme Cascade for Controlled Synthesis of Furancarboxylic Acids from 5‐Hydroxymethylfurfural by H2O2Internal Recycling
| Autor: | Ning Li, Min-Hua Zong, Gao-Wei Zheng, Hao-Yu Jia |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nicotinamide
biology General Chemical Engineering Alcohol 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Horseradish peroxidase Cofactor 0104 chemical sciences Catalysis Enzyme catalysis chemistry.chemical_compound General Energy chemistry Biocatalysis Galactose oxidase biology.protein Environmental Chemistry Organic chemistry General Materials Science 0210 nano-technology |
| Zdroj: | ChemSusChem. 12:4764-4768 |
| ISSN: | 1864-564X 1864-5631 |
| DOI: | 10.1002/cssc.201902199 |
| Popis: | Furancarboxylic acids are promising biobased building blocks in pharmaceutical and polymer industries. In this work, dual-enzyme cascade systems composed of galactose oxidase (GOase) and alcohol dehydrogenases (ADHs) are constructed for controlled synthesis of 5-formyl-2-furancarboxylic acid (FFCA) and 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF), based on the catalytic promiscuity of ADHs. The byproduct H2 O2 , which is produced in GOase-catalyzed oxidation of HMF to 2,5-diformylfuran (DFF), is used for horseradish peroxidase (HRP)-mediated regeneration of the oxidized nicotinamide cofactors for subsequent oxidation of DFF promoted by an ADH, thus implementing H2 O2 internal recycling. The desired products FFCA and FDCA are obtained with yields of more than 95 %. |
| Databáze: | OpenAIRE |
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