Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity

Autor:	Gui-Hua Lai, Yu-Lan Huang, Bai-Yu Zhang
Rok vydání:	2017
Předmět:	0301 basic medicine Chemistry Stereochemistry Endometrial cancer General Chemistry medicine.disease Combinatorial chemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Proton NMR Single crystal
Zdroj:	Russian Journal of General Chemistry. 87:1053-1056
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363217050267
Popis:	Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl- and 3-cyanophenyl-substituted derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c1b245192d82d23f73c04b867573a38 https://doi.org/10.1134/s1070363217050267 Zobrazit plný text záznamu Plný text ve formátu PDF