Static cold storage compared with normothermic machine perfusion of the liver and effect on ischaemic-type biliary lesions after transplantation: a propensity score-matched study
| Autor: | Felix J. Krendl, Theresa Hautz, Manuel Maglione, Andras T. Meszaros, R. Oberhuber, Heinz Zoller, Benjamin Henninger, S. Schneeberger, Franka Messner, Christina Bogensperger, Thomas Resch, Margot Fodor, Giorgi Otarashvili, Wolfgang Peter, Dietmar Öfner, Herbert Tilg, Silvia Gasteiger, Benno Cardini, Christian Margreiter, Annemarie Weissenbacher |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Machine perfusion Bile duct business.industry medicine.medical_treatment Urology Postoperative complication Cold storage 030230 surgery Liver transplantation Transplantation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine 030211 gastroenterology & hepatology Surgery Complication business Perfusion |
| Zdroj: | British Journal of Surgery. 108:1082-1089 |
| ISSN: | 1365-2168 0007-1323 |
| Popis: | Background Given the susceptibility of organs to ischaemic injury, alternative preservation methods to static cold storage (SCS), such as normothermic machine perfusion (NMP) are emerging. The aim of this study was to perform a comparison between NMP and SCS in liver transplantation with particular attention to bile duct lesions. Methods The outcomes of 59 consecutive NMP-preserved donor livers were compared in a 1 : 1 propensity score-matched fashion to SCS control livers. Postoperative complications, patient survival, graft survival and bile duct lesions were analysed. Results While patients were matched for cold ischaemia time, the total preservation time was significantly longer in the NMP group (21 h versus 7 h, P Conclusion The use of NMP allowed for a significantly prolonged organ preservation with a lower rate of observed ischaemic-type bile duct lesions. |
| Databáze: | OpenAIRE |
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