Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP-2
| Autor: | J. Fred Dice, Ichizo Nishino, Ana Maria Cuervo, Ignacio V. Sandoval, Eeva-Liisa Eskelinen, Paul Saftig, J. Thomas August, Matthew R.G. Taylor, Jennifer Lippincott-Schwartz, Janice S. Blum |
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| Rok vydání: | 2005 |
| Předmět: |
Gene isoform
0303 health sciences LAMP2 genetic structures LAMP1 Alternative splicing Cell Biology Biology Biochemistry eye diseases Cell biology 03 medical and health sciences 0302 clinical medicine Type (biology) medicine.anatomical_structure Membrane protein Structural Biology Lysosome Genetics medicine splice sense organs Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Traffic. 6:1058-1061 |
| ISSN: | 1398-9219 |
| DOI: | 10.1111/j.1600-0854.2005.00337.x |
| Popis: | The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C. |
| Databáze: | OpenAIRE |
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