Causes Underlying the Reduced Response to Simvastatin Treatment in Hypercholesterolemic Patients

Autor:	Franco Pazzucconi, Remo Fumagalli, A. Granata, Tiziano Zanelli, Alberico Catapano, Patrizia Uboldi, Domenico Sommariva, Maria Mazzotti, Alberto Corsini, Antonio Vittorino Gaddi, Cesare R. Sirtori, Giancarlo Descovish
Rok vydání:	1993
Předmět:	medicine.medical_specialty Mutation Apolipoprotein B biology business.industry Probucol Reductase medicine.disease_cause Endocrinology Plasma cholesterol Simvastatin Internal medicine LDL receptor biology.protein Medicine lipids (amino acids peptides and proteins) In patient business medicine.drug
Zdroj:	Human Apolipoprotein Mutants III ISBN: 9783642846366
Popis:	Simvastatin, a competitive inhibitor of HMG-CoA reductase, effectively reduces elevated plasma cholesterol levels by up regulating the LDL receptor expression. Therefore in patients whose hypercholesterolemia (HC) is due to a defective LDL-receptor interaction vastatins may not be as effective as expected. To verify this hypothesis we studied the possible causes for the poor response (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5c02c00aca155e2d6cba1f322c8a7649 https://doi.org/10.1007/978-3-642-84634-2_19 Zobrazit plný text záznamu