Autor: |
Franco Pazzucconi, Remo Fumagalli, A. Granata, Tiziano Zanelli, Alberico Catapano, Patrizia Uboldi, Domenico Sommariva, Maria Mazzotti, Alberto Corsini, Antonio Vittorino Gaddi, Cesare R. Sirtori, Giancarlo Descovish |
Rok vydání: |
1993 |
Předmět: |
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Zdroj: |
Human Apolipoprotein Mutants III ISBN: 9783642846366 |
Popis: |
Simvastatin, a competitive inhibitor of HMG-CoA reductase, effectively reduces elevated plasma cholesterol levels by up regulating the LDL receptor expression. Therefore in patients whose hypercholesterolemia (HC) is due to a defective LDL-receptor interaction vastatins may not be as effective as expected. To verify this hypothesis we studied the possible causes for the poor response ( |
Databáze: |
OpenAIRE |
Externí odkaz: |
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