Neuroprotective Properties of Melatonin in a Model of Birth Asphyxia in the Spiny Mouse (Acomys cahirinus)

Autor:	Hayley Dickinson, Lisa Cathleen Hutton, David Walker, Mahila Abbass, Z. Ireland
Rok vydání:	2009
Předmět:	Asphyxia Pregnancy biology Physiology Brain damage biology.organism_classification medicine.disease Neuroprotection Melatonin Developmental Neuroscience Neurology Spiny mouse Anesthesia medicine Gestation Precocial medicine.symptom medicine.drug
Zdroj:	Developmental Neuroscience. 31:437-451
ISSN:	1421-9859 0378-5866
DOI:	10.1159/000232562
Popis:	Birth asphyxia is associated with disturbed development of the neonatal brain. In this study, we determined if low-dose melatonin (0.1 mg/kg/day), administered to the mother over 7 days at the end of pregnancy, could protect against the effects of birth asphyxia in a precocial species – the spiny mouse (Acomys cahirinus). At 37 days of gestation (term is 38–39 days), pups were subjected to birth asphyxia (7.5 min uterine ischemia) and compared to Cesarean section-delivered controls. At 24 h of age, birth asphyxia had increased markers of CNS inflammation (microglia, macrophage infiltration) and apoptosis (activated caspase-3, fractin) in cortical gray matter, which were reduced to control levels by prior maternal melatonin treatment. Melatonin may be an effective prophylactic agent for use in late pregnancy to protect against hypoxic-ischemic brain injury at birth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5bfa95939a4843f753f04acfe2f0c6c0 https://doi.org/10.1159/000232562 Zobrazit plný text záznamu