Octatjumidylates involving alternating neopentylphosphothionotriester-phosphodiester linkages with controlled stereochemistry at the modified p-center

Autor:	Thuong N.T, Hau J.F, Asseline U
Rok vydání:	1991
Předmět:	Nuclease biology Stereochemistry Dimer Organic Chemistry Biochemistry chemistry.chemical_compound Deoxyribonucleotide chemistry Covalent bond Drug Discovery Acridine Phosphodiester bond biology.protein Derivative (chemistry) Conjugate
Zdroj:	Tetrahedron Letters. 32:2497-2498
ISSN:	0040-4039
Popis:	Starting from each pure stereoisomer of neopentylphosphothionotriester dimer, octathymidylates involving alternating stereoregular neopentylphosphothionotriester-phosphodiester linkages and covalently linked to an acridine derivative at their 3′-end have been synthesized. Their stability towards nuclease degradation was studied by comparison with an octanucleotide-acridine conjugate containing only phosphodiester groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5bf66dc0253b3a2d6ab325aa0f48ef01 https://doi.org/10.1016/s0040-4039(00)74364-4 Zobrazit plný text záznamu