Synthesis and biodistribution study of a new211At-calix[4]arene complex
Autor: | Thomas A. Waldmann, Alexander T. Yordanov, Kayhan Garmestani, Martin W. Brechbiel, Bert Herring, Hisataka Kobayashi, Kim A. Deal |
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Rok vydání: | 2000 |
Předmět: | |
Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 43:1219-1225 |
ISSN: | 1099-1344 0362-4803 |
Popis: | The preparation and characterization of a new tetramercaptocalix[4]arene and its 211At complex is described. The in vivo stability of the complex has been evaluated in nude mice for the purpose of α-radioimmunotherapy of cancer. The study shows that while this complex lacks adequate stability in vivo, 211At may behave as a heavy metal ion and may be successfully sequestered for biomedical applications. Copyright © 2000 John Wiley & Sons, Ltd. |
Databáze: | OpenAIRE |
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