Synthesis and biodistribution study of a new211At-calix[4]arene complex

Autor:	Thomas A. Waldmann, Alexander T. Yordanov, Kayhan Garmestani, Martin W. Brechbiel, Bert Herring, Hisataka Kobayashi, Kim A. Deal
Rok vydání:	2000
Předmět:	Biodistribution Stereochemistry Organic Chemistry Biochemistry Chemical synthesis Analytical Chemistry Inclusion compound chemistry.chemical_compound Immunoradiotherapy chemistry In vivo Drug Discovery Calixarene Radiology Nuclear Medicine and imaging Chemical stability Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 43:1219-1225
ISSN:	1099-1344 0362-4803
Popis:	The preparation and characterization of a new tetramercaptocalix[4]arene and its 211At complex is described. The in vivo stability of the complex has been evaluated in nude mice for the purpose of α-radioimmunotherapy of cancer. The study shows that while this complex lacks adequate stability in vivo, 211At may behave as a heavy metal ion and may be successfully sequestered for biomedical applications. Copyright © 2000 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5bef5fb9c3f014c72d31eee4a521f7c3 https://doi.org/10.1002/1099-1344(20001030)43:12<1219::aid-jlcr409>3.0.co Zobrazit plný text záznamu Plný text