Genomic Insights and Its Comparative Analysis with Yersinia enterocolitica Reveals the Potential Virulence Determinants and Further Pathogenicity for Foodborne Outbreaks
| Autor: | Eun Jung Na, Ju-Hoon Lee, Gopalsamy Gnanasekaran, Han Young Chung, Heebal Kim, Woori Kwak, You-Tae Kim, Su-Yeon Kim, Sang-Ho Choi, Sangryeol Ryu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
biology Yersinia Infections Virulence General Medicine Enterotoxin biology.organism_classification Applied Microbiology and Biotechnology Virulence factor Microbiology Bacterial adhesin 03 medical and health sciences genomic DNA 030104 developmental biology Yersinia enterocolitica Pathogen Biotechnology |
| Zdroj: | Journal of Microbiology and Biotechnology. 27:262-270 |
| ISSN: | 1738-8872 1017-7825 |
| DOI: | 10.4014/jmb.1611.11048 |
| Popis: | Yersinia enterocolitica is a well-known foodborne pathogen causing gastrointestinal infections worldwide. The strain Y. enterocolitica FORC_002 was isolated from the gill of flatfish (plaice) and its genome was sequenced. The genomic DNA consists of 4,837,317 bp with a GC content of 47.1%, and is predicted to contain 4,221 open reading frames, 81 tRNA genes, and 26 rRNA genes. Interestingly, genomic analysis revealed pathogenesis and host immune evasion-associated genes encoding guanylate cyclase (Yst), invasin (Ail and Inv), outer membrane protein (Yops), autotransporter adhesin A (YadA), RTX-like toxins, and a type III secretion system. In particular, guanylate cyclase is a heat-stable enterotoxin causing Yersinia-associated diarrhea, and RTX-like toxins are responsible for attachment to integrin on the target cell for cytotoxic action. This genome can be used to identify virulence factors that can be applied for the development of novel biomarkers for the rapid detection of this pathogen in foods. |
| Databáze: | OpenAIRE |
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