Fecal total iron concentration is inversely associated with fecalLactobacillusin preschool children
| Autor: | Sivaraman Kuppuswamy, Balamurugan Ramadass, Giriprasad Venugopal, Sasank Kalipatnapu, Venkatesh Kaliaperumal |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Hepatology Gastroenterology Iron deficiency Biology medicine.disease_cause medicine.disease biology.organism_classification Microbiology 03 medical and health sciences 030104 developmental biology Animal science Gut bacteria Lactobacillus Cohort medicine Iron supplementation Escherichia coli Feces Bacteria |
| Zdroj: | Journal of Gastroenterology and Hepatology. 32:1475-1479 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.13725 |
| Popis: | Background Iron deficiency is associated with stunting and poor performance in children. Oral iron supplementation is widely promoted to correct iron deficiency. However, excess iron may be toxic to beneficial luminal gut bacteria and could support growth of pathobionts. Objective To analyze the fecal total iron concentration and fecal Lactobacillus levels in a cohort of stunted and normal children. Design The study was undertaken in two different locations. One of them is a rural area and other is a semi-urban-slum area, both areas are located in the Vellore district of Tamilnadu state. 20 children (10 stunted and 10 normal growth) aged 2 to 5 years from each area were recruited. Both groups were nearly identical demographically. Fecal samples were collected. Fecal total iron was estimated, fecal DNA was extracted and subjected to 16S rDNA-targeted real-time polymerase chain reaction to determine the relative predominance of Lactobacillus and Escherichia coli. Results The fecal total iron concentration in rural children (3656 µg/ g wet wt. of feces) was significantly higher when compared to semi-urban-slum children (114.9 µg/ g wet wt. of feces, p |
| Databáze: | OpenAIRE |
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