| Popis: |
Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients their role is still controversial and no data about the possible correlation with the BRCA-status has been ever reported.We consecutively enrolled a series of 397 newly diagnosed high-grade serous-advanced OC-patients. All patients were tested for BRCA-mutational-status and blood-parameters have been collected 48 hours before staging-surgery. A significant correlation of NLR with disease distribution (p< 4 had a significant 7-month increase in mPFS (26 vs 19 months, p=0.009); focusing on the BRCA-status, among both BRCA-mutated and BRCA-wild type patients, those with lower NLR had a significantly prolonged mPFS compared to patients with NLR> 4 (BRCA-mutated: 35 vs 23 months, p= 0.03; BRCA-wt: 19 vs 16 months, p=0.05). At multivariate-analysis, independent factors of prolonged PFS were BRCA mutational status, having received complete cytoreduction and NLR< 4. Also, the strongest predictors of longer OS were BRCA-mutational status, having received complete, NLR< 4 and age.NLR is confirmed to be a prognostic marker in OC-patients and it seems unrelated with BRCA-mutational status. |
