| Autor: |
Lena Samuelsson, Patricia Momigliano-Richiardi, A.S. Louka, Ludvig M. Sollid, J. Ek, S. Percopo, A. H. Gudjonsdottir, Iolanda Coto, Jan Wahlström, Henry Ascher, Sandra D'Alfonso, Marta Mellai, Luigi Greco, Å. Torinsson Naluai, Mara Giordano |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Tissue Antigens. 59:70-72 |
| ISSN: |
0001-2815 |
| DOI: |
10.1034/j.1399-0039.2002.590117.x |
| Popis: |
Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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