| Autor: |
N. Fragoso-Bargas, C.M. Page, B.R. Joubert, S.J. London, S. Lee-Ødegård, J.O. Opsahl, L. Sletner, A.K. Jenum, E. Qvigstad, R.B. Prasad, G.-H. Moen, K.I. Birkeland, C. Sommer |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.11.23.22282639 |
| Popis: |
AimTo perform an epigenome-wide association study (EWAS) of serum folate in maternal blood.MethodsWe performed cross-ancestry (Europeans=302, South Asians=161) and ancestry-specific EWAS in the EPIPREG cohort, followed by methyl quantitative trait loci (mQTL) analysis and association with cardiometabolic phenotypes. We attempted replication using folate intake estimated from a food frequency questionnaire and maternal blood methylation data from MoBa, and in a previous published EWAS of maternal serum folate in cord blood.Resultscg19888088 (cross-ancestry) inEBF3, cg01952260 (Europeans), and cg07077240 (South Asians) inHERC3were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants inCASC15. The findings were not replicated in the independent samples.ConclusionSerum folate was associated with methylation at three CpG sites. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
