LaCl3.7H2O: An efficient catalyst for the synthesis of phosphinates (Michaelis–Arbuzov reaction) under neat conditions and their potential antimicrobial activity

Autor:	Venkata Ramana Katla, Rasheed Syed, Naresh Kondapalli, Subba Rao Devineni, Madhava Golla, Naga Raju Chamarthi
Rok vydání:	2014
Předmět:	Antifungal Michaelis–Arbuzov reaction medicine.drug_class Chemistry medicine Halide Organic chemistry General Chemistry Efficient catalyst Heterogeneous catalysis Antimicrobial Catalysis
Zdroj:	Journal of Chemical Sciences. 126:117-125
ISSN:	0973-7103 0974-3626
DOI:	10.1007/s12039-013-0550-3
Popis:	An expeditious neat procedure was developed for the synthesis of a series of new methyl phenyl heterocyclic phosphinates (3a–l) through Michaelis–Arbuzov reaction by the reaction of various heterocyclic halides (Cl or Br) (1a–l) with dimethyl phenylphosphonite (2) under N2 atmosphere using a heterogeneous catalyst, LaCl3.7H2O. The advantages of the developed procedure are good yields (80–89%) of the products, less reaction time (2–3 h), avoiding toxic catalysts and harmful solvents and easy work-up procedure. Further, antimicrobial activity of the synthesized compounds was evaluated at different concentrations 50, 100 and 150 μg/mL. Biological data revealed that compounds 3i, 3j and 3h, 3j exhibited potential antibacterial and antifungal activities, respectively, while the rest of the compounds showed moderate antimicrobial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5bc7eae5fa9063113e8c0be9b8372c99 https://doi.org/10.1007/s12039-013-0550-3 Zobrazit plný text záznamu Plný text ve formátu PDF