Experimental model of optic nerve sheath fenestration Histology, ultrastructure, and glial immunocytochemistry

Autor:	Agnès Muller, Bernard Arnaud, Max Villain, Alain Privat, F. Sandillon, Emmanuel Candon
Rok vydání:	1995
Předmět:	Optic nerve sheath Pathology medicine.medical_specialty genetic structures business.industry Immunocytochemistry Axonal loss Meninges Histology Anatomy eye diseases Ophthalmology medicine.anatomical_structure Ultrastructure Optic nerve Medicine sense organs business Fenestration
Zdroj:	Orbit. 14:113-122
ISSN:	1744-5108 0167-6830
DOI:	10.3109/01676839509150042
Popis:	Optic nerve sheath fenestration is a surgical procedure for the treatment of many optic neuropathies. The authors developed an experimental model carried out on healthy adult rabbits in order to study the morphological consequences of an iatrogenic meningeal 'breach' in optic nerve axons, macroglia, and meninges corresponding to optic nerve fenestration. The fibrous scar which developed at the level of the fenestration was accompanied by glial hypertrophy, along with meningeal laminae which were stuck together. There was no axonal loss, but there were reactive astrocytes with gliofilament bundles. These morphological data assisted the authors in building up hypotheses which partly explain the acknowledged efficiency of this procedure for specific optic neuropathies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5bc63cfc10a2125061e88c6bc58f711e https://doi.org/10.3109/01676839509150042 Zobrazit plný text záznamu