New Flavanol Dimers from the Bark of Celtis tetrandra and Their TRAIL Resistance-Overcoming Activity
| Autor: | Thaworn Kowithayakorn, Prapairat Seephonkai, Masami Ishibashi, Ryusho Ishikawa, Midori A. Arai, Takashi Koyano |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Traditional medicine 010405 organic chemistry Chemistry Celtis tetrandra Catechin Plant Science General Medicine 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine visual_art Drug Discovery visual_art.visual_art_medium Bark Trail resistance |
| Zdroj: | Natural Product Communications. 13:1934578X1801300 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1801300412 |
| Popis: | In the courses of our search for bioactive natural products on TRAIL resistance-overcoming activity, the active EtOAc extract from the bark of Celtis tetrandra was chemically investigated. The fractionation of the extract resulted in the isolation of flavanols; (+)-afzelechin (1), (-)- epiafzelechin (2), (-)-catechin (3), and two new flavanol dimers; (-)- epiafzelechin-(4α→8)-(-)-catechin (4) and (-)- epiafzelechin-(4α→8)-(-)- epicatechin (5). All isolated compounds 1-5 were tested for their TRAIL resistance-overcoming activity against AGS cells at the concentrations from 5–20 μM. It is likely that the flavanol dimers 4 and 5 exhibited weak activity in the range of the concentration of 10–20 μM as compared with the standard. |
| Databáze: | OpenAIRE |
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