The Influence of Roentgen Rays on the Growth and Phosphatase Activity of Bone

Autor:	Eugene M. Regen, Walter E. Wilkins
Rok vydání:	1934
Předmět:	Bone growth medicine.medical_specialty business.industry Phosphatase Roentgen Anatomy Roentgen rays symbols.namesake Endocrinology Internal medicine medicine symbols Radiology Nuclear Medicine and imaging Irradiation business
Zdroj:	Radiology. 22:674-677
ISSN:	1527-1315 0033-8419
DOI:	10.1148/22.6.674
Popis:	SHORTLY after the discovery of the roentgen ray, it was found that exposure of growing bone to this ray is followed by a period of inhibited growth. Brooks and Hillstrom (1) have recently made a study of the amount of irradiation necessary to inhibit growth, the quantity of the effect produced, the duration of the influence, and the coincident histologic changes. In view of the significance attached by Robison (3, 4, 5) and other workers to the role of phosphatase in bone growth, it appeared to us that a simultaneous study of the effect of roentgen rays on growth and on phosphatase activity would be of interest. The results of such a study are given in this paper. ProcedurePups from 30 to 40 days of age, were exposed to approximately 600 roentgens over the left fore leg, the remainder of the animal's body being carefully protected with sheet lead. The factors constituting this dose were from 190 to 200 kilovolts, 20 milliamperes, target-skin distance of 55 centimeters, filter of 0.5 mm. copper and 1 mm. a...
Databáze:	OpenAIRE
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