| Popis: |
Natural products and their plant-derived analogs are often a source of drugs or drug templates with limited toxicity, which has the potential to mitigate compliance issues during protracted administration.Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) infection, represents a major health problem globally. Despite the introduction of inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen 40 years ago, TB continues to cause considerable morbidity and mortality worldwide. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. Since ancient times, different plant part extracts have been used as traditional medicines against diseases including tuberculosis. This knowledge may be useful in developing future powerful drugs. In this regard this review article is an attempt to investigate the antimycobacterial activity of the spices as an alternative and highlight them for further investigation as leads for drug development. The choice of spice as an alternative is based on two basic reasons: firstly, plants have been the model source of medicine since ancient times and secondly, the increasing acceptance of herbal medicines by general population. |
