Evaluation of salvage surgery in heavily irradiated cancer of the buccal mucosa

Autor: R. Sankaranarayanan, Gladys Jeevy, M. Iqbal Ahamed, P Sebastian, K. L. Jayakumar, P. Sivaramakrishnan, Thomas Cherian, M. Krishnan Nair
Rok vydání: 1991
Předmět:
Zdroj: Cancer. 68:295-299
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19910715)68:2<295::aid-cncr2820680214>3.0.co;2-a
Popis: This report describes the authors' experience with salvage surgery in 78 patients with carcinoma of the buccal mucosa who failed after high-dose radical radiation therapy at Regional Cancer Centre, Trivandrum, India. Forty-four patients (56%) required a hemimandibulectomy for adequate tumor clearance. Fifty-four patients (69%) required a primary reconstructive procedure for wound closure. Follow-up periods ranged from 28 months to 63 months (median follow-up, 41 months). Thirteen patients (17%) developed nonfatal postoperative complications. Thirty-one patients recurred after surgery, five of whom were again salvaged by further surgery. Overall, the recurrence rate was 36%. Most of the recurrences (26/31) were at the primary site. The overall 5-year actuarial disease-free survival after salvage surgery was 59.7%. T stage of the recurrent tumor and its skin infiltration emerged as factors which significantly influenced disease-free survival (P less than 0.05).
Databáze: OpenAIRE
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