| Autor: |
Z Ademovic, Minela Dacić, S Pilipovic, S. Osmancevic, Aida Šapčanin, A Uzunovic |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
IFMBE Proceedings ISBN: 9783030179700 |
| DOI: |
10.1007/978-3-030-17971-7_84 |
| Popis: |
Capsaicin has been applied topically to treat some peripheral painful states, such as rheumatoid arthritis, cancer pain and diabetic neuropathy. Due to the pre-systemic metabolism of intragastric capsaicin and very rapid elimination half-life made topical application of capsaicin advantageous. The aim of this study was to evaluate differences in the dissolution characteristics of capsaicin transdermal patches commercially available on the local market (formulation I, II and III). USP Apparatus 5 (Paddle Over Disc) is used for transdermal patch release testing at fixed rotation speed (50 rpm). The 9 cm2 patch was exposed to 500 mL of phosphate buffer solution pH 4.0, 5.0 and 7.4. All dissolution studies were carried out at 32 ± 0.5 °C and samples were collected at various time intervals (60, 240, 480 and 720 min) and analyzed for capsaicin content using optimized and validated high-performance liquid chromatography (HPLC). The mobile phase consisted of acetonitrile:water (50:50 v/v). pH change in the release media showed no significant difference in capsaicin release profile for formulation I and II. For formulation III, the resulting results vary considerably with pH change. Although several apparatus and procedures have been used to study in vitro release characteristics of transdermal patches, USP Apparatus 5 could be considered as a discriminatory test that would be able to detect the differences in the dissolution rate of all tested capsaicin patches at short sampling intervals (1–12 h). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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