Chemical and pharmacological analysis of the crude aqueous/alcoholic extract fromCordyline dracaenoides

Autor: R. A. Yunes, João B. Calixto, Rosa Maria Ribeiro do Valle, C.C. Schmidt, T.C.M. De Lima, Reinaldo N. Takahashi, Gina Struffaldi Morato, Mauro Nicolau
Rok vydání: 1990
Předmět:
Zdroj: Phytotherapy Research. 4:167-171
ISSN: 1099-1573
0951-418X
Popis: Chemical analysis of Cordyline dracaenoides (Kunth) demonstrated the presence of steroidal saponins and anthocyanidins in the stem, rhizome and root. Small amounts of tannins were also detected in its stem and rhizome. Pharmacological analysis revealed different effects according to the part of the plant used. Crude aqueous/alcoholic extract (CE) from the rhizome inhibited carrageenan-induced rat paw oedema, while the CE obtained from the root significantly decreased the locomotor activity and potentiated barbiturate-induced hypnosis in mice. The CE from the roots inhibited noradrenaline-induced contraction in the rat vas deferens in a concentration-dependent and a noncompetitive manner, while the CE from the rhizome caused a parallel displacement to the left of noradrenaline concentration response curves. In the isolated rat stomach, the CE from the roots promoted a concentration-dependent displacement to the right of the serotonin concentration response curve allied to a marked inhibition of its maximal response, while the CE from the rhizome produced only an inhibition of about 40% of serotonin-contractile responses. These results suggest that the CE from C. dracaenoides exhibits a potent and long lasting antioedematogenic effect, has central depressant effects and potentiates noradrenaline-induced contractile responses of the isolated rat vas deferens. All these effects may be, at least in part, related to the presence of steroidal saponins in this plant.
Databáze: OpenAIRE
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