| Autor: |
Speck, K. E., K Lund, P., Rigby, R. J., Scull, B. P., Helmrath, M. A., Hunt, M. R., Simmons, J. G. |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| DOI: |
10.17615/qdef-mh43 |
| Popis: |
Ileo-cecal resection (ICR) is common in Crohn’s disease (CD). Inflammation and fibrosis frequently recur at the site of anastomosis or in the small intestine (SI). No animal models of post-surgical inflammation and fibrosis exist. We developed a model of ICR in IL-10 null and wild-type (WT) mice to test the hypothesis that that ICR promotes post-surgical inflammation and fibrosis in SI or anastomosis of genetically susceptible IL-10 null, but not WT or germ free (GF)-IL-10 null mice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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