GABA Receptors in the Modulation of Fear Memory Extinction
| Autor: | N. I. Dubrovina |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fear processing in the brain GABAA receptor General Neuroscience Central nervous system social sciences Extinction (psychology) GABAB receptor Inhibitory postsynaptic potential humanities 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system medicine GABAergic Memory consolidation Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Behavioral Physiology. 47:573-584 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-017-0438-7 |
| Popis: | γ-Aminobutyric acid (GABA) is a the main inhibitory transmitter in the central nervous system, which determines the efficiency of neuronal interactions. GABA receptors play a key role in various stages of fear memory – formation, consolidation, retention, reconsolidation, and extinction. Extinction is an important behavioral phenomenon which allows the body to adapt its behavior to changes in the surrounding world. Fear memory extinction constitutes “new” learning, which interferes with the expression of a previously acquired conditioned fear reaction. This review summarizes our own and published data on the GABAergic modulation of fear memory extinction and the potential for pharmacological correction of impairments to this process by actions on GABAA and GABAB receptors. |
| Databáze: | OpenAIRE |
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